Michael Harris

Associate Professor

University of Alaska Fairbanks
PO Box 757000
Fairbanks, Alaska 99775
● Neuroscience  ● Integrated Physiology
   (IDeA Network of Biomedical Research Excellence)
●  University of Alaska Fairbanks
   Chemistry and Biochemistry
   Institute of Arctic Biology
●  Sudden Infant Death Syndrome
●  Breathing and functional consequences of
    brainstem deficits
● B.S. 1990 Zoology
   University of British Columbia, Vancouver BC
M.S. 1992 Zoology
   University of British Columbia
● Ph.D. 1997 Zoology
   University of British Columbia
● Post Doctoral 2000 Neuro-Physiology
    University of Calgary, Calgary, Alberta
● Research Associate 2003 Neuro-Physiology
    Dartmouth Medical School, Lebanon NH
Peer Reviewed Publications
1.  Castellini M, Milsom W, Berger R, Costa D, Jones D, Castellini J, Rea L, Bharma S, Harris M (1993) Patterns of respiration and heart rate during wakefulness and sleep in elephant seal pups. Am J Physiol 266:R863-R869.
2.  Harris MB, Milsom WK (1994) The ventilatory response to hypercapnia in hibernating golden-mantled ground squirrels. Physiol Zool 67:739-755.
3.  Harris MB, Milsom WK (1995) Parasympathetic influence on heart rate in euthermic and hibernating ground squirrels. J Exp Biol 198:931-937.
4.  Milsom W, Castellini M, Harris M, Castellini J, Jones D, Berger R, Bharma S, Rea L, Costa D (1996) Hypoxia, hypercapnia and cardiorespiratory patterns of sleep-associated apnea in elephant seal pups. Am J Physiol Regul Integr Comp Physiol 271:R1017-24.
5.  Kinkead R, Harris M, Milsom W (1997) The role of the Nucleus Isthmi in respiratory pattern formation in bullfrogs. J Exp Biol 200:1781-1793.
6.  Milsom WK, Harris MB, Reid SG (1997) Do descending excitatory and inhibitory inputs interact to produce episodic breathing? Respir Physiol 110:307-317.
7.  Carefoot TH, Harris MB, Taylor BE, Donovan D, Karentz D (1998) Mycosporine amino acids: possible UV- protection in eggs of the sea hare, Aplysia dactylomela. Mar Biol 130:389-396.
8.  Milsom WK, Zimmer MB, Harris MB (1999) Regulation of cardiac rhythm in hibernation. Comp Biochem Physiol A Mol Integr Physiol 124: 383-391.
9.  Harris MB, Milsom WK (2000) Is hibernation facilitated by an inhibition of arousal? In: Heldmaier G, Klaus S, and Klingenspor M (eds) Life in the Cold. Springer, New York. Pp.241-250.
10. Zimmer MB, Harris MB, Milsom WK (2000) Control of cardiac and ventilation frequencies during hibernation in ground squirrels. In: Heldmaier G, Klaus S, and Klingenspor M (eds) Life in the Cold. Springer, New York. Pp.159-167.
11. Wilson RJA, Harris MB, Remmers JE, Perry SF (2000) Evolution of air-breathing and central CO2/H+ sensitivity: New insights from an old fish. J Exp Biol 203:3505-3512.
12. Harris MB, Milsom WK (2001) The influence of NMDA receptor-mediated processes on breathing pattern in ground squirrels. Respir Physiol  125:181-197.
13. Harris MB, Milsom WK (2001) Vagal feedback is essential for breathing in ground squirrels. Respir Physiol 125:199-212.
14. Remmers JE, Torgerson C, Harris M, Perry SF, Vasilakos K, Wilson RJ (2001) Evolution of central respiratory chemoreception: a new twist on an old story. Respir Physiol 129(1-2):211-7.
15. Perry SF, Wilson RJ, Straus C, Harris MB, Remmers JE (2001) Which came first, the lung or the breath? Comp Biochem Physiol A Mol Integr Physiol 129:37-47.
16. Milsom WK, Zimmer MB, Harris MB (2001) Vagal control of cardiorespiratory function in hibernation. Exp Physiol 86(6):791-6.
17. Wilson RJ, Vasilakos K, Harris MB, Straus C, Remmers JE (2002) Evidence that ventilatory rhythmogenesis in the frog involves two distinct neuronal oscillators. J Physiol (Lond) 540:557-70.
18. Harris MB, Wilson RJ, Vasilakos K, Taylor BE, Remmers JE (2002) Central respiratory activity of the tadpole in vitro brain stem is modulated diversely by nitric oxide. Am J Physiol Regul Integr Comp Physiol 283:R417-28.
19. Taylor BE, Harris MB, Burk M, Smyth K, Lukowiak K, Remmers JE (2003) Nitric oxide mediates metabolism as well as respiratory and cardiac responses to hypoxia in the snail lymnaea stagnalis. J Exp Zoolog Part A Comp Exp Biol 295:37-46.
20. Taylor BE, Harris MB, Coates EL, Gdovin MJ, Leiter JC (2003) Central CO2 chemoreception in developing bullfrogs: anomalous response to acetazolamide. J Appl Physiol 94:1204-12.
21. Harris MB, St -John WM (2003) Tonic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation. Am J Physiol Regul Integr Comp Physiol 285:R215-21.
22. Harris MB, Milsom WK (2003) Apneusis follows disruption of NMDA-type glutamate receptors in vagotomized ground squirrels. Respir Physiol Neurobiol 134: 191-207.
23. Taylor BE, Harris MB, Leiter JC, Gdovin MJ (2003) Ontogeny of central CO2 chemoreception: chemosensitivity in the ventral medulla of developing bullfrogs. Am J Physiol Regul Integr Comp Physiol 285:R1461-72.
24. Drew KL, Harris MB, LaManna JC, Smith MA, ZHU XW, Ma YL (2004) Hypoxia tolerance in mammalian heterotherms. J Exp Biol 207:3155-62.
25. Harris MB, Olson LE, Milsom WK (2004) The origin of mammalian heterothermy: a case for perpetual youth. In: Life in the Cold: Evolution, Mechanisms, Adaptation, and Application. Twelfth International Hibernation Symposium. Barnes BM and Carey HV (Eds.). Biological Papers of Alaska, number 27. Institute of Arctic Biology, University of Alaska Fairbanks, Alaska, USA. Pp 41-50.
26. St.-John WM, Rudkin AH, Harris MB, Leiter JC, Paton JFR (2005) Maintenance of eupnea and gasping following alterations in potassium concentration of perfusates of in situ rat preparation. J Neurosci Meth 142:125-9. (PMID: 15652625).
27. Harris MB, St -John WM (2005) Phasic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation. Am J Physiol Regul Integr Comp Physiol 289:R450-R455 (PMID: 15831763).
28. Darnall RA, Harris MB,Gill WH, Hoffman JM, Brown JW, Niblock MM (2005) Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases REM in the piglet: Implications for the Sudden Infant Death Syndrome. J Neurosci 7;25:8322-32 (PMID: 16148240)
29. Rodman JR, Harris MB, St.-John WM, Leiter JC (2006) Gap junction blockade does not alter eupnea or gasping in the juvenile rat. Respir Physiol Neurobiol 152:51-60.
30. Drew KL, Buck CL, Barnes BM, Christian SL, Rasley BT, Harris MB. (2007) Central nervous system regulation of mammalian hibernation: implications for metabolic suppression and ischemia tolerance. J Neurochem 102:1713-26.
31. Hoffman JM, Brown JW, Sirlin EA, Benoit AM, Gill WG, Harris MB, Darnall RA. (2007). Activation of 5-HT1A receptors in the paragigantocellularis lateralis decreases shivering but not peripheral vasoconstriction during cooling in the conscious piglet. Am.J. Physiol: Reg. Int. Comp. Physiol.  Am J Physiol Regul Integr Comp Physiol 293:R518-27 ( PMID: 17409258).
32. Toppin VL, Harris MB, Kober AM, Leiter JC, St.-John WM. (2007) Persistence of Eupnea and Gasping Following Blockade of Both Serotonin Type 1 and 2 Receptors in the In Situ Juvenile Rat Preparation. J Appl Physiol 103:220-7 (PMID: 17412795).
33. Duffy L, Bult-Ito A, Castillo M, Drew K, Harris M, Kuhn T, Ma Y, Schulte M, Taylor B, van Muelken M. (2007) Arctic Peoples and Beyond: research opportunities in neuroscience and behaviour. Int J Circumpolar Health 66:264-75.
34. Hodges MR, Tattersall GJ, Harris MB, McEvoy SD, Richerson DN, Deneris ES, Johnson RL, Chen ZF, Richerson GB (2008). Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J Neurosci 28:2495-505. (PMID: 18322094).
35. Wilson RJA, Taylor BE, Harris MB. (2009) Evolution of vertebrate respiratory neural control. In: Encyclopedia of Neuroscience (4th Ed.), Adelman G and Smith BH (Eds). Elsevier Ltd., Pp 67-75.
36. Davies BL, Brundage CM, Harris MB, Taylor BE. (2009). Lung respiratory rhythm and pattern generation in the bullfrog: role of neurokinin-1 and mu-opioid receptors. J Comp Physiol B 79:579-92. (PMID: 19184042).
37. Corcoran, AE, Richerson, GB, and Harris, MB. (2010). Modulation of respiratory activity by hypocretin-1 (orexin A) in situ and in vitro.  Adv Exp Med Biol. 2010;669:109-13 (PMID:   20217331).
38. Corcoran, AE, Richerson, GB, and Harris, MB. (2010). Serotonergic mechanisms are critical for central neuroventilatory chemosensitivity in situ. Am J Physiol Reg Int Comp Physiol (Submitted, in review).